Physiological Alterations due to Hepatotoxicity and the Protective Role of Cleome viscosa Linn Seed Extract in Experimental Animals

Liver ailment is a key public health menace, principally in developing nations. Quite lot of medicinal florae have been identified to liver shielding activities. The current study was designed assess vitro antioxidant and vivo hepatoprotective activities seed extracts Cleome viscosa Linn. (Capparaceae). Phytochemical screening C. ethanol extract carried out. Free radical scavenging activity crude the plant conducted using DPPH assay method. DNA damage protection potential out genomic nicking assay. Hepatoprotective based on CCl4-induced Wister albino rats. Serum biomarkers (aspartate transaminase (AST), alanine (ALT), alkaline phosphatase (ALP), total protein (TP)) were evaluated find effect. Histopathological scrutiny also for all groups rats further confirm discoveries. phytochemical positive alkaloids, flavonoids, saponins, steroids, terpenes, tannins, phenolic compounds extract. revealed that exhibited free with IC50 value 17.82 ± 0.32 μg/mL, this confirmed by activity. Pretreatment significantly reduced ALP ( p < 0.05). histopathological studies. From study, it can be concluded For reason, future, oral intake as an adjunct natural therapy may worthwhile protect against failure-mediated inhibitory effects reproductive function.